| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 2 |
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| Ligand | BDBM50546004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2013746 (CHEMBL4667324) |
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| EC50 | 6100±n/a nM |
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| Citation |  Iwaki, Y; Yashiro, K; Kokubo, M; Mori, T; Wieting, JM; McGowan, KM; Bridges, TM; Engers, DW; Denton, JS; Kurata, H; Lindsley, CW Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett29:1601-1604 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 2 |
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| Name: | Potassium channel subfamily K member 2 |
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| Synonyms: | KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1 |
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| Type: | Protein |
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| Mol. Mass.: | 47099.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95069 |
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| Residue: | 426 |
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| Sequence: | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
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| BDBM50546004 |
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| n/a |
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| Name | BDBM50546004 |
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| Synonyms: | CHEMBL4759521 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H8BrF4NO3S |
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| Mol. Mass. | 438.192 |
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| SMILES | OC(=O)c1cc(Br)c(F)cc1NC(=O)c1ccc(SC(F)(F)F)cc1 |
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| Structure | 
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