| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
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| Ligand | BDBM38019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2014903 (CHEMBL4668481) |
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| Kd | 73±n/a nM |
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| Citation |  Yuan, X; Bu, H; Zhou, J; Yang, CY; Zhang, H Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application. J Med Chem63:11368-11396 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
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| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 68443.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06124 |
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| Residue: | 593 |
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| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| BDBM38019 |
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| n/a |
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| Name | BDBM38019 |
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| Synonyms: | US10093646, Compound 1 | US10301278, Example 00003 | US10336774, Example 01 | US10774065, Example 00003 | US10858359, SHP099 | US11401259, Compound 1 | US11702392, Compound SHP-099 | US20230348467, Compound SHP-099 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19Cl2N5 |
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| Mol. Mass. | 352.262 |
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| SMILES | CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |
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| Structure | 
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