| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50104963 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105198 (CHEMBL713837) |
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| Ki | 171±n/a nM |
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| Citation |  Yao, W; Wasserman, ZR; Chao, M; Reddy, G; Shi, E; Liu, RQ; Covington, MB; Arner, EC; Pratta, MA; Tortorella, M; Magolda, RL; Newton, R; Qian, M; Ribadeneira, MD; Christ, D; Wexler, RR; Decicco, CP Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. J Med Chem44:3347-50 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50104963 |
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| n/a |
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| Name | BDBM50104963 |
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| Synonyms: | (2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-3-(3-hydroxybenzyl)succinamide | (3R)-N~2~-(cyclopropylmethyl)-N~1~-hydroxy-3-(3-hydroxybenzyl)-N~4~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-L-aspartamide | (R)-2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydroxy-benzyl)-N*4*-((3S,3aR)-2-hydroxy-indan-1-yl)-succinamide | 2-(Cyclopropylmethyl-amino)-N*1*-hydroxy-3-(3-hydroxy-benzyl)-N*4*-(2-hydroxy-indan-1-yl)-succinamide | CHEMBL24398 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N3O5 |
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| Mol. Mass. | 439.5042 |
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| SMILES | ONC(=O)[C@@H](NCC1CC1)[C@@H](Cc1cccc(O)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r| |
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| Structure | 
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