| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator BAX |
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| Ligand | BDBM50547486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2018355 (CHEMBL4671933) |
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| EC50 | 2218±n/a nM |
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| Citation |  Liang, T; Zhou, Y; Elhassan, RM; Hou, X; Yang, X; Fang, H HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells. J Med Chem63:12083-12099 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator BAX |
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| Name: | Apoptosis regulator BAX |
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| Synonyms: | Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21181.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_100916 |
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| Residue: | 192 |
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| Sequence: | MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGV
LTASLTIWKKMG
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| BDBM50547486 |
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| n/a |
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| Name | BDBM50547486 |
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| Synonyms: | CHEMBL4790418 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H24N8O4S2 |
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| Mol. Mass. | 648.714 |
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| SMILES | ONC(=O)\C=C\c1ccc(CNC(=O)c2ccc(cc2)-c2csc(n2)N2N=C(\C(=N\Nc3nccs3)C2=O)c2ccccc2)cc1 |c:28| |
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| Structure | 
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