Reaction Details |
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Target | Macrophage migration inhibitory factor |
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Ligand | BDBM50547499 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2018482 (CHEMBL4672060) |
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Kd | 6860±n/a nM |
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Citation | Cirillo, PF; Asojo, OA; Khire, U; Lee, Y; Mootien, S; Hegan, P; Sutherland, AG; Peterson-Roth, E; Ledizet, M; Koski, RA; Anthony, KG Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders. ACS Med Chem Lett11:1843-1847 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage migration inhibitory factor |
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Name: | Macrophage migration inhibitory factor |
Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase |
Type: | Enzyme |
Mol. Mass.: | 12478.18 |
Organism: | Homo sapiens (Human) |
Description: | P14174 |
Residue: | 115 |
Sequence: | MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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BDBM50547499 |
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n/a |
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Name | BDBM50547499 |
Synonyms: | CHEMBL4785454 |
Type | Small organic molecule |
Emp. Form. | C28H25N5O8S2 |
Mol. Mass. | 623.657 |
SMILES | CC(C)C(=O)c1c(Cc2cccc(c2)\N=N\c2ccc3c(cc(c(N)c3c2O)S(O)(=O)=O)S(O)(=O)=O)nn2ccccc12 |
Structure |
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