| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50106059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208873 |
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| IC50 | >10000±n/a nM |
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| Citation |  Su, T; Wu, Y; Doughan, B; Jia, ZJ; Woolfrey, J; Huang, B; Wong, P; Park, G; Sinha, U; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett11:2947-50 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50106059 |
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| n/a |
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| Name | BDBM50106059 |
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| Synonyms: | 3-Carbamimidoyl-N-[(R)-2-methyl-1-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl)-propyl]-benzamide | CHEMBL101654 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N5O4S |
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| Mol. Mass. | 493.578 |
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| SMILES | CC(C)[C@@H](NC(=O)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O |
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| Structure | 
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