| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50114789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2019809 (CHEMBL4673622) |
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| IC50 | 67±n/a nM |
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| Citation |  Mekala, S; Nelson, G; Li, YM Recent developments of small molecule ?-secretase modulators for Alzheimer's disease. RSC Med Chem11:1003-1022 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50114789 |
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| n/a |
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| Name | BDBM50114789 |
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| Synonyms: | CHEMBL3609747 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClF6O3 |
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| Mol. Mass. | 480.828 |
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| SMILES | OC(=O)[C@H](CC1CCC1)c1cc(Cl)c(OCC(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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