Reaction Details |
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Target | Platelet-activating factor acetylhydrolase |
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Ligand | BDBM50107480 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_101009 |
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IC50 | 0.200000±n/a nM |
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Citation | Boyd, HF; Fell, SC; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Pinto, IL; Rawlings, DA; Smith, SA; Stansfield, IG; Stanway, SJ; Theobald, CJ; Whittaker, CM Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. Bioorg Med Chem Lett12:51-5 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor acetylhydrolase |
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Name: | Platelet-activating factor acetylhydrolase |
Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
Type: | PROTEIN |
Mol. Mass.: | 50084.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156212 |
Residue: | 441 |
Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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BDBM50107480 |
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n/a |
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Name | BDBM50107480 |
Synonyms: | CHEMBL348243 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5-(2-piperazin-1-yl-pyrimidin-5-ylmethyl)-4H-pyrimidin-1-yl]-N-methyl-acetamide |
Type | Small organic molecule |
Emp. Form. | C36H35ClFN7O2S |
Mol. Mass. | 684.225 |
SMILES | CN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1cc(Cc2cnc(nc2)N2CCNCC2)c(=O)nc1SCc1ccc(F)cc1 |
Structure |
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