| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
|---|
| Ligand | BDBM50107579 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_105370 |
|---|
| Ki | 691±n/a nM |
|---|
| Citation |  Yao, W; Chao, M; Wasserman, ZR; Liu, RQ; Covington, MB; Newton, R; Christ, D; Wexler, RR; Decicco, CP Potent P1' biphenylmethyl substituted aggrecanase inhibitors. Bioorg Med Chem Lett12:101-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Matrix metalloproteinase-9 |
|---|
| Name: | Matrix metalloproteinase-9 |
|---|
| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 78452.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14780 |
|---|
| Residue: | 707 |
|---|
| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
|
|
|
|---|
| BDBM50107579 |
|---|
| n/a |
|---|
| Name | BDBM50107579 |
|---|
| Synonyms: | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(3'-methanesulfonylamino-biphenyl-4-ylmethyl)-succinamide | CHEMBL8655 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29N3O6S |
|---|
| Mol. Mass. | 523.601 |
|---|
| SMILES | CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](CC(=O)NO)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
