| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 3 |
|---|
| Ligand | BDBM50107595 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_90295 (CHEMBL698775) |
|---|
| Ki | 2137±n/a nM |
|---|
| Citation |  Campiani, G; Morelli, E; Nacci, V; Fattorusso, C; Ramunno, A; Novellino, E; Greenwood, J; Liljefors, T; Griffiths, R; Sinclair, C; Reavy, H; Kristensen, AS; Pickering, DS; Schousboe, A; Cagnotto, A; Fumagalli, E; Mennini, T Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. J Med Chem44:4501-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor 3 |
|---|
| Name: | Glutamate receptor 3 |
|---|
| Synonyms: | GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 100383.57 |
|---|
| Organism: | RAT |
|---|
| Description: | Glutamate-AMPA GRIA3 RAT::P19492 |
|---|
| Residue: | 888 |
|---|
| Sequence: | MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNW
QVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLN
EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
|
|
|
|---|
| BDBM50107595 |
|---|
| n/a |
|---|
| Name | BDBM50107595 |
|---|
| Synonyms: | (S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cyclopenta[d]-pyrimidin-2,4(1H,3H)dione | (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID | 2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclopentapyrimidin-1-yl)-propionic acid | CHEMBL337577 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H13N3O4 |
|---|
| Mol. Mass. | 239.2279 |
|---|
| SMILES | N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
