| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta-2B chain |
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| Ligand | BDBM50107656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_211341 (CHEMBL815034) |
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| IC50 | 810.0±n/a nM |
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| Citation |  Mahboobi, S; Pongratz, H; Hufsky, H; Hockemeyer, J; Frieser, M; Lyssenko, A; Paper, DH; Bürgermeister, J; Böhmer, FD; Fiebig, HH; Burger, AM; Baasner, S; Beckers, T Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem44:4535-53 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta-2B chain |
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| Name: | Tubulin beta-2B chain |
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| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49932.38 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_211651 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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| BDBM50107656 |
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| n/a |
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| Name | BDBM50107656 |
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| Synonyms: | (3,5-Dimethoxy-phenyl)-(5-methoxy-1H-indol-2-yl)-methanone | CHEMBL141508 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NO4 |
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| Mol. Mass. | 311.3319 |
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| SMILES | COc1ccc2[nH]c(cc2c1)C(=O)c1cc(OC)cc(OC)c1 |
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| Structure | 
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