| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50108258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205884 |
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| Ki | 6±n/a nM |
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| Citation |  Shih, NY; Albanese, M; Anthes, JC; Carruthers, NI; Grice, CA; Lin, L; Mangiaracina, P; Reichard, GA; Schwerdt, J; Seidl, V; Wong, SC; Piwinski, JJ Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides. Bioorg Med Chem Lett12:141-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50108258 |
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| n/a |
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| Name | BDBM50108258 |
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| Synonyms: | CHEMBL285986 | {3-(3,4-Dichloro-phenyl)-5-(4-hydroxy-4-phenyl-piperidin-1-yl)-2-[(Z)-methoxyimino]-pentyl}-methyl-carbamic acid 3,5-bis-trifluoromethyl-phenyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C33H33Cl2F6N3O4 |
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| Mol. Mass. | 720.529 |
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| SMILES | CO\N=C(/CN(C)C(=O)Oc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(CCN1CCC(O)(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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