Reaction Details |
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Target | Sorbitol dehydrogenase |
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Ligand | BDBM50108756 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201010 (CHEMBL882165) |
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IC50 | 350±n/a nM |
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Citation | Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Berger, R; Coutcher, JB; Day, WW; Li, J; Mylari, BL; Oates, PJ; Weekly, RM Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. J Med Chem45:511-28 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sorbitol dehydrogenase |
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Name: | Sorbitol dehydrogenase |
Synonyms: | DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD |
Type: | PROTEIN |
Mol. Mass.: | 38332.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_223910 |
Residue: | 357 |
Sequence: | MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
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BDBM50108756 |
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n/a |
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Name | BDBM50108756 |
Synonyms: | CHEMBL151268 | {4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-methanol |
Type | Small organic molecule |
Emp. Form. | C15H20N6O |
Mol. Mass. | 300.3589 |
SMILES | Cc1cc(C)nc(n1)N1CCN(CC1)c1ccnc(CO)n1 |
Structure |
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