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Compile Data Set for Download or QSAR

Found 180 hits with Last Name = 'coutcher' and Initial = 'jb'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16315
PNG
(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Show SMILES Cc1c(oc2ccc(Cl)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C13H9ClN2O4S/c1-7-9-6-8(14)2-3-10(9)20-13(7)21(18,19)12-5-4-11(17)15-16-12/h2-6H,1H3,(H,15,17)
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n/an/a 0.840n/an/an/an/a7.024



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 46: 2283-6 (2003)


Article DOI: 10.1021/jm034065z
BindingDB Entry DOI: 10.7270/Q2NV9GGM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16315
PNG
(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Show SMILES Cc1c(oc2ccc(Cl)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C13H9ClN2O4S/c1-7-9-6-8(14)2-3-10(9)20-13(7)21(18,19)12-5-4-11(17)15-16-12/h2-6H,1H3,(H,15,17)
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n/an/a 1n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16633
PNG
(6-[(5-fluoro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Show SMILES Cc1c(oc2ccc(F)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C13H9FN2O4S/c1-7-9-6-8(14)2-3-10(9)20-13(7)21(18,19)12-5-4-11(17)15-16-12/h2-6H,1H3,(H,15,17)
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n/an/a 3n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16452
PNG
((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Show SMILES OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)
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n/an/a 4n/an/an/an/a7.024



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 46: 2283-6 (2003)


Article DOI: 10.1021/jm034065z
BindingDB Entry DOI: 10.7270/Q2NV9GGM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118706
PNG
((S)-1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C21H32N8O/c1-15-13-28(14-16(2)29(15)19-6-7-22-20(24-19)17(3)30)18-5-8-23-21(25-18)27-11-9-26(4)10-12-27/h5-8,15-17,30H,9-14H2,1-4H3/t15-,16+,17-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118710
PNG
(1-(4-{4-[2-(2,4-Dimethyl-imidazol-1-yl)-pyrimidin-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)-n1cc(C)nc1C
Show InChI InChI=1S/C21H28N8O/c1-13-10-28(17(5)24-13)21-23-9-6-18(26-21)27-11-14(2)29(15(3)12-27)19-7-8-22-20(25-19)16(4)30/h6-10,14-16,30H,11-12H2,1-5H3/t14-,15+,16-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118709
PNG
(1-{4-[2,6-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(C)n1
Show InChI InChI=1S/C16H23N7O/c1-10-7-22(16-19-9-18-13(4)20-16)8-11(2)23(10)14-5-6-17-15(21-14)12(3)24/h5-6,9-12,24H,7-8H2,1-4H3/t10-,11+,12-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113497
PNG
(1-(4-{(2S,6R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)=O
Show InChI InChI=1S/C18H24N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-13,25H,9-10H2,1-4H3/t11-,12+,13-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16634
PNG
(6-{[3-methyl-5-(trifluoromethyl)-1-benzofuran-2-]s...)
Show SMILES Cc1c(oc2ccc(cc12)C(F)(F)F)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C14H9F3N2O4S/c1-7-9-6-8(14(15,16)17)2-3-10(9)23-13(7)24(21,22)12-5-4-11(20)18-19-12/h2-6H,1H3,(H,18,20)
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n/an/a 5n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113497
PNG
(1-(4-{(2S,6R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)=O
Show InChI InChI=1S/C18H24N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-13,25H,9-10H2,1-4H3/t11-,12+,13-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against human recombinant sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118706
PNG
((S)-1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C21H32N8O/c1-15-13-28(14-16(2)29(15)19-6-7-22-20(24-19)17(3)30)18-5-8-23-21(25-18)27-11-9-26(4)10-12-27/h5-8,15-17,30H,9-14H2,1-4H3/t15-,16+,17-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16636
PNG
(6-[(5-chloro-3-ethyl-1-benzofuran-2-)sulfonyl]-2,3...)
Show SMILES CCc1c(oc2ccc(Cl)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C14H11ClN2O4S/c1-2-9-10-7-8(15)3-4-11(10)21-14(9)22(19,20)13-6-5-12(18)16-17-13/h3-7H,2H2,1H3,(H,16,18)
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n/an/a 6n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118708
PNG
(1-{4-[2,6-Dimethyl-4-(4-phenyl-[1,3,5]triazin-2-yl...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(n1)-c1ccccc1
Show InChI InChI=1S/C21H25N7O/c1-14-11-27(21-24-13-23-20(26-21)17-7-5-4-6-8-17)12-15(2)28(14)18-9-10-22-19(25-18)16(3)29/h4-10,13-16,29H,11-12H2,1-3H3/t14-,15+,16-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118710
PNG
(1-(4-{4-[2-(2,4-Dimethyl-imidazol-1-yl)-pyrimidin-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)-n1cc(C)nc1C
Show InChI InChI=1S/C21H28N8O/c1-13-10-28(17(5)24-13)21-23-9-6-18(26-21)27-11-14(2)29(15(3)12-27)19-7-8-22-20(25-19)16(4)30/h6-10,14-16,30H,11-12H2,1-5H3/t14-,15+,16-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118709
PNG
(1-{4-[2,6-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(C)n1
Show InChI InChI=1S/C16H23N7O/c1-10-7-22(16-19-9-18-13(4)20-16)8-11(2)23(10)14-5-6-17-15(21-14)12(3)24/h5-6,9-12,24H,7-8H2,1-4H3/t10-,11+,12-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108732
PNG
(1-{4-[4-(3-Methyl-quinoxalin-2-yl)-piperazin-1-yl]...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nc2ccccc2nc1C
Show InChI InChI=1S/C19H22N6O/c1-13-19(22-16-6-4-3-5-15(16)21-13)25-11-9-24(10-12-25)17-7-8-20-18(23-17)14(2)26/h3-8,14,26H,9-12H2,1-2H3/t14-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113491
PNG
(1-(4-{(3S,5R)-4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-y...)
Show SMILES CC(O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13?,14?
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n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat Sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118711
PNG
(1-{4-[4-(4,6-Dimethyl-[1,3,5]triazin-2-yl)-2,6-dim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(C)n1
Show InChI InChI=1S/C17H25N7O/c1-10-8-23(17-20-13(4)19-14(5)21-17)9-11(2)24(10)15-6-7-18-16(22-15)12(3)25/h6-7,10-12,25H,8-9H2,1-5H3/t10-,11+,12-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118711
PNG
(1-{4-[4-(4,6-Dimethyl-[1,3,5]triazin-2-yl)-2,6-dim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(C)n1
Show InChI InChI=1S/C17H25N7O/c1-10-8-23(17-20-13(4)19-14(5)21-17)9-11(2)24(10)15-6-7-18-16(22-15)12(3)25/h6-7,10-12,25H,8-9H2,1-5H3/t10-,11+,12-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118708
PNG
(1-{4-[2,6-Dimethyl-4-(4-phenyl-[1,3,5]triazin-2-yl...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(n1)-c1ccccc1
Show InChI InChI=1S/C21H25N7O/c1-14-11-27(21-24-13-23-20(26-21)17-7-5-4-6-8-17)12-15(2)28(14)18-9-10-22-19(25-18)16(3)29/h4-10,13-16,29H,11-12H2,1-3H3/t14-,15+,16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113496
PNG
((S)-1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108762
PNG
(1-(4-{4-[2-(2-Hydroxy-ethyl)-pyrimidin-4-yl]-2,6-d...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(CCO)n1
Show InChI InChI=1S/C18H26N6O2/c1-12-10-23(16-4-7-19-15(21-16)6-9-25)11-13(2)24(12)17-5-8-20-18(22-17)14(3)26/h4-5,7-8,12-14,25-26H,6,9-11H2,1-3H3/t12-,13+,14-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113494
PNG
((R)-1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against human recombinant sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118712
PNG
(1-(4-{2,6-Dimethyl-4-[2-(4-methyl-imidazol-1-yl)-p...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)-n1cnc(C)c1
Show InChI InChI=1S/C20H26N8O/c1-13-9-27(12-23-13)20-22-8-5-17(25-20)26-10-14(2)28(15(3)11-26)18-6-7-21-19(24-18)16(4)29/h5-9,12,14-16,29H,10-11H2,1-4H3/t14-,15+,16-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113496
PNG
((S)-1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108754
PNG
(1-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-py...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C17H19N5OS/c1-12(23)16-18-7-6-15(19-16)21-8-10-22(11-9-21)17-13-4-2-3-5-14(13)24-20-17/h2-7,12,23H,8-11H2,1H3/t12-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108758
PNG
(1-(4-{4-[2-(2-Hydroxy-ethyl)-pyrimidin-4-yl]-2-met...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(C[C@H]1C)c1ccnc(CCO)n1
Show InChI InChI=1S/C17H24N6O2/c1-12-11-22(15-3-6-18-14(20-15)5-10-24)8-9-23(12)16-4-7-19-17(21-16)13(2)25/h3-4,6-7,12-13,24-25H,5,8-11H2,1-2H3/t12-,13-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118712
PNG
(1-(4-{2,6-Dimethyl-4-[2-(4-methyl-imidazol-1-yl)-p...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)-n1cnc(C)c1
Show InChI InChI=1S/C20H26N8O/c1-13-9-27(12-23-13)20-22-8-5-17(25-20)26-10-14(2)28(15(3)11-26)18-6-7-21-19(24-18)16(4)29/h5-9,12,14-16,29H,10-11H2,1-4H3/t14-,15+,16-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16635
PNG
(6-[(3,5-dimethyl-1-benzofuran-2-)sulfonyl]-2,3-dih...)
Show SMILES Cc1c(oc2ccc(C)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C14H12N2O4S/c1-8-3-4-11-10(7-8)9(2)14(20-11)21(18,19)13-6-5-12(17)15-16-13/h3-7H,1-2H3,(H,15,17)
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n/an/a 13n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50118711
PNG
(1-{4-[4-(4,6-Dimethyl-[1,3,5]triazin-2-yl)-2,6-dim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(C)n1
Show InChI InChI=1S/C17H25N7O/c1-10-8-23(17-20-13(4)19-14(5)21-17)9-11(2)24(10)15-6-7-18-16(22-15)12(3)25/h6-7,10-12,25H,8-9H2,1-5H3/t10-,11+,12-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113494
PNG
((R)-1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113493
PNG
(1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)C(C)=O
Show InChI InChI=1S/C18H24N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-12,14,26H,9-10H2,1-4H3/t11-,12+,14-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113498
PNG
((R)-1-(4-{(3S,5R)-4-[2-((S)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against human recombinant Sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113493
PNG
(1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)C(C)=O
Show InChI InChI=1S/C18H24N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-12,14,26H,9-10H2,1-4H3/t11-,12+,14-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against human recombinant sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108765
PNG
(1-{4-[4-(4-Hydroxymethyl-6-methyl-pyrimidin-2-yl)-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nc(C)cc(CO)n1
Show InChI InChI=1S/C16H22N6O2/c1-11-9-13(10-23)19-16(18-11)22-7-5-21(6-8-22)14-3-4-17-15(20-14)12(2)24/h3-4,9,12,23-24H,5-8,10H2,1-2H3/t12-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50118713
PNG
(1-{4-[4-(4-Hydroxymethyl-6-methyl-[1,3,5]triazin-2...)
Show SMILES C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(CO)n1
Show InChI InChI=1S/C17H25N7O2/c1-10-7-23(17-20-13(4)19-14(9-25)21-17)8-11(2)24(10)15-5-6-18-16(22-15)12(3)26/h5-6,10-12,25-26H,7-9H2,1-4H3/t10-,11+,12-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16638
PNG
(6-(3-Phenylbenzofuran-2-sulfonyl)-2H-pyridazin-3-o...)
Show SMILES O=c1ccc(n[nH]1)S(=O)(=O)c1oc2ccccc2c1-c1ccccc1
Show InChI InChI=1S/C18H12N2O4S/c21-15-10-11-16(20-19-15)25(22,23)18-17(12-6-2-1-3-7-12)13-8-4-5-9-14(13)24-18/h1-11H,(H,19,21)
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n/an/a 23n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108724
PNG
(1-{4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nc(C)cc(C)n1
Show InChI InChI=1S/C16H22N6O/c1-11-10-12(2)19-16(18-11)22-8-6-21(7-9-22)14-4-5-17-15(20-14)13(3)23/h4-5,10,13,23H,6-9H2,1-3H3/t13-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108742
PNG
(1-[4-(3-Methyl-4-oxazolo[5,4-c]pyridin-2-yl-pipera...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN([C@@H](C)C1)c1nc2ccncc2o1
Show InChI InChI=1S/C17H20N6O2/c1-11-10-22(15-4-6-19-16(21-15)12(2)24)7-8-23(11)17-20-13-3-5-18-9-14(13)25-17/h3-6,9,11-12,24H,7-8,10H2,1-2H3/t11-,12+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108717
PNG
(1-[4-(4-Oxazolo[5,4-c]pyridin-2-yl-piperazin-1-yl)...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nc2ccncc2o1
Show InChI InChI=1S/C16H18N6O2/c1-11(23)15-18-5-3-14(20-15)21-6-8-22(9-7-21)16-19-12-2-4-17-10-13(12)24-16/h2-5,10-11,23H,6-9H2,1H3/t11-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16457
PNG
(6-[(5-chloro-1-benzofuran-2-)sulfonyl]-2,3-dihydro...)
Show SMILES Clc1ccc2oc(cc2c1)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C12H7ClN2O4S/c13-8-1-2-9-7(5-8)6-12(19-9)20(17,18)11-4-3-10(16)14-15-11/h1-6H,(H,14,16)
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n/an/a 25n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16457
PNG
(6-[(5-chloro-1-benzofuran-2-)sulfonyl]-2,3-dihydro...)
Show SMILES Clc1ccc2oc(cc2c1)S(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C12H7ClN2O4S/c13-8-1-2-9-7(5-8)6-12(19-9)20(17,18)11-4-3-10(16)14-15-11/h1-6H,(H,14,16)
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n/an/a 25n/an/an/an/a7.024



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 46: 2283-6 (2003)


Article DOI: 10.1021/jm034065z
BindingDB Entry DOI: 10.7270/Q2NV9GGM
More data for this
Ligand-Target Pair
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM16620
PNG
(6-{[(2-chloro-6-fluorophenyl)methane]sulfonyl}-2,3...)
Show SMILES Fc1cccc(Cl)c1CS(=O)(=O)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C11H8ClFN2O3S/c12-8-2-1-3-9(13)7(8)6-19(17,18)11-5-4-10(16)14-15-11/h1-5H,6H2,(H,14,16)
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n/an/a 26n/an/an/an/an/an/a



Pfizer



Assay Description
The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...

J Med Chem 48: 6326-39 (2005)


Article DOI: 10.1021/jm050462t
BindingDB Entry DOI: 10.7270/Q2RN363Z
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50102724
PNG
(4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C12H21N5O3S/c1-10(18)12-13-5-4-11(14-12)16-6-8-17(9-7-16)21(19,20)15(2)3/h4-5,10,18H,6-9H2,1-3H3/t10-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human SDH

J Med Chem 44: 2695-700 (2001)


BindingDB Entry DOI: 10.7270/Q21G0KJZ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113498
PNG
((R)-1-(4-{(3S,5R)-4-[2-((S)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat Sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50113491
PNG
(1-(4-{(3S,5R)-4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-y...)
Show SMILES CC(O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13?,14?
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n/an/a 28n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against human recombinant Sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50113496
PNG
((S)-1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrim...)
Show SMILES C[C@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@@H](C)O
Show InChI InChI=1S/C18H26N6O2/c1-11-9-23(15-5-7-19-17(21-15)13(3)25)10-12(2)24(11)16-6-8-20-18(22-16)14(4)26/h5-8,11-14,25-26H,9-10H2,1-4H3/t11-,12+,13-,14+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat sorbitol dehydrogenase

Bioorg Med Chem Lett 12: 1477-80 (2002)


BindingDB Entry DOI: 10.7270/Q2XS5TPQ
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108722
PNG
(1-{4-[4-(2,6-Dimethyl-pyrimidin-4-yl)-piperazin-1-...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1cc(C)nc(C)n1
Show InChI InChI=1S/C16H22N6O/c1-11-10-15(19-13(3)18-11)22-8-6-21(7-9-22)14-4-5-17-16(20-14)12(2)23/h4-5,10,12,23H,6-9H2,1-3H3/t12-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Homo sapiens (Human))		BDBM50108734
PNG
(1-[4-(4-Oxazolo[5,4-b]pyridin-2-yl-piperazin-1-yl)...)
Show SMILES C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1nc2cccnc2o1
Show InChI InChI=1S/C16H18N6O2/c1-11(23)14-17-6-4-13(20-14)21-7-9-22(10-8-21)16-19-12-3-2-5-18-15(12)24-16/h2-6,11,23H,7-10H2,1H3/t11-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro inhibition of recombinant human sorbitol dehydrogenase (h-SDH)

J Med Chem 45: 511-28 (2002)


BindingDB Entry DOI: 10.7270/Q2R210QX
More data for this
Ligand-Target Pair
Sorbitol dehydrogenase


(Rattus norvegicus)		BDBM50409605
PNG
(CHEMBL2111939)
Show SMILES C[C@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C21H32N8O/c1-15-13-28(14-16(2)29(15)19-6-7-22-20(24-19)17(3)30)18-5-8-23-21(25-18)27-11-9-26(4)10-12-27/h5-8,15-17,30H,9-14H2,1-4H3/t15-,16+,17-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)

J Med Chem 45: 4398-401 (2002)


BindingDB Entry DOI: 10.7270/Q2V69HZM
More data for this
Ligand-Target Pair
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