| Reaction Details |
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 | Report a problem with these data |
| Target | Sorbitol dehydrogenase |
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| Ligand | BDBM50108746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_201003 (CHEMBL801253) |
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| IC50 | 37±n/a nM |
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| Citation |  Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Berger, R; Coutcher, JB; Day, WW; Li, J; Mylari, BL; Oates, PJ; Weekly, RM Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. J Med Chem45:511-28 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sorbitol dehydrogenase |
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| Name: | Sorbitol dehydrogenase |
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| Synonyms: | DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38332.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_223910 |
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| Residue: | 357 |
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| Sequence: | MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
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| BDBM50108746 |
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| n/a |
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| Name | BDBM50108746 |
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| Synonyms: | 1-[4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-pyrimidin-2-yl]-ethanol | CHEMBL151764 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N5O2 |
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| Mol. Mass. | 325.3651 |
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| SMILES | C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1noc2ccccc12 |
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| Structure | 
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