| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aromatase |
|---|
| Ligand | BDBM50051358 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_50718 |
|---|
| IC50 | 28500±n/a nM |
|---|
| Citation |  Pouget, C; Fagnere, C; Basly, JP; Habrioux, G; Chulia, AJ New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. Bioorg Med Chem Lett12:1059-61 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aromatase |
|---|
| Name: | Aromatase |
|---|
| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57888.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11511 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
|
|
|
|---|
| BDBM50051358 |
|---|
| n/a |
|---|
| Name | BDBM50051358 |
|---|
| Synonyms: | 2,3-Dihydroflavone | 2,3-dihydro-2-phenyl-4H-1-benzopyran-4-one | 2-phenyl-2,3-dihydro-4H-chromen-4-one | 2-phenyl-4-chromanone | CHEMBL274318 | Flavanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12O2 |
|---|
| Mol. Mass. | 224.2546 |
|---|
| SMILES | O=C1CC(Oc2ccccc12)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
