Ki Summary

Reaction Details

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Target

DNA polymerase I, thermostable

Ligand

BDBM50111322

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_209735

IC50

5000±n/a nM

Citation

Alberti, P; Schmitt, P; Nguyen, CH; Rivalle, C; Hoarau, M; Grierson, DS; Mergny, JL Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase. Bioorg Med Chem Lett12:1071-4 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

DNA polymerase I, thermostable

Name:

DNA polymerase I, thermostable

Synonyms:

DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA

Type:

PROTEIN

Mol. Mass.:

93906.95

Organism:

Thermus aquaticus

Description:

ChEMBL_1289218

Residue:

832

Sequence:

MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE

BDBM50111322

n/a

Name

BDBM50111322

Synonyms:

CHEMBL274335 | N,N-Dimethyl-N'-(11-nitro-13H-5,13-diaza-dibenzo[a,i]fluoren-6-yl)-propane-1,3-diamine

Type

Small organic molecule

Emp. Form.

C24H23N5O2

Mol. Mass.

413.4717

SMILES

CN(C)CCCNc1nc2ccccc2c2[nH]c3c(ccc4ccc(cc34)[N+]([O-])=O)c12

Structure