| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet glycoprotein VI |
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| Ligand | BDBM50357312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2033139 (CHEMBL4687297) |
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| IC50 | 120±n/a nM |
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| Citation |  Foster, H; Wilson, C; Philippou, H; Foster, R Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. J Med Chem63:12213-12242 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet glycoprotein VI |
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| Name: | Platelet glycoprotein VI |
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| Synonyms: | GP6 | GPVI | GPVI_HUMAN | Glycoprotein 6 | Platelet glycoprotein VI |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36878.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109099 |
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| Residue: | 339 |
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| Sequence: | MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLE
KLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQP
GPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRC
YSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFT
TETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRH
RGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
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| BDBM50357312 |
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| n/a |
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| Name | BDBM50357312 |
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| Synonyms: | IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compound 1 | US10711006, Compound Ibrutinib | US10793575, Example ibrutinib | US10835536, Ref. Ex. Comp 1 | US10919899, Ibrutinib | US11078206, Example Ibrutinib | US11186578, Example Ibrutinib | US11339167, Example Ibrutinib | US11407754, Example Ibrutinib | US20230364079, Example Ibrutinib | US20240059694, Compound Ibrutinib | US9108973, Ref 1 | US9181263, 1 | US9278100, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N6O2 |
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| Mol. Mass. | 440.4971 |
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| SMILES | Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C |
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| Structure | 
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