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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Coagulation factor X | ||
| Ligand | BDBM50111672 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_209063 | ||
| Ki | 2±n/a nM | ||
| Citation |  St-Denis, Y; Lévesque, S; Bachand, B; Edmunds, JJ; Leblond, L; Préville, P; Tarazi, M; Winocour, PD; Siddiqui, MA Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors. Bioorg Med Chem Lett12:1181-4 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Coagulation factor X | |||
| Name: | Coagulation factor X | ||
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54726.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50111672 | |||
| n/a | |||
| Name | BDBM50111672 | ||
| Synonyms: | (6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid (4-carbamimidoyl-cyclohexylmethyl)-amide | CHEMBL17735 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H37N5O4S | ||
| Mol. Mass. | 551.7 | ||
| SMILES | NC(=N)[C@H]1CC[C@H](CNC(=O)[C@@H]2CC[C@H]3CN(CC(=O)N23)S(=O)(=O)C(c2ccccc2)c2ccccc2)CC1 |wU:11.10,3.2,wD:14.21,6.6,(18.98,-7.59,;17.96,-8.75,;18.42,-10.22,;16.46,-8.41,;15.41,-9.57,;13.92,-9.24,;13.45,-7.8,;11.96,-7.48,;11.48,-6.01,;9.97,-5.69,;8.95,-6.84,;9.5,-4.22,;10.39,-2.99,;9.48,-1.74,;8.03,-2.22,;6.68,-1.45,;5.37,-2.22,;5.35,-3.76,;6.68,-4.53,;6.68,-6.07,;8.03,-3.76,;4.02,-1.45,;5.12,-.35,;2.93,-.35,;2.69,-2.23,;2.78,-3.76,;1.48,-4.6,;1.56,-6.14,;2.93,-6.84,;4.23,-6,;4.15,-4.46,;1.33,-1.52,;.03,-2.36,;-1.33,-1.67,;-1.42,-.12,;-.12,.72,;1.24,.02,;14.47,-6.65,;15.97,-6.96,)| | ||
| Structure | 
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