| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
|---|
| Ligand | BDBM50435473 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2035041 (CHEMBL4689199) |
|---|
| IC50 | 8.0±n/a nM |
|---|
| Citation |  Brahmaiah, D; Kanaka Durga Bhavani, A; Aparna, P; Sampath Kumar, N; Solhi, H; Le Guevel, R; Baratte, B; Ruchaud, S; Bach, S; Singh Jadav, S; Raji Reddy, C; Roisnel, T; Mosset, P; Levoin, N; Grée, R Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase. Bioorg Med Chem31:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK1 |
|---|
| Name: | Dual specificity protein kinase CLK1 |
|---|
| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57322.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49759 |
|---|
| Residue: | 484 |
|---|
| Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
|
|
|
|---|
| BDBM50435473 |
|---|
| n/a |
|---|
| Name | BDBM50435473 |
|---|
| Synonyms: | CHEMBL1236620 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13Cl2N3O2 |
|---|
| Mol. Mass. | 338.189 |
|---|
| SMILES | CCOC(=O)c1c(C(C=N)C#N)c2ccc(Cl)c(Cl)c2n1C |
|---|
| Structure | 
|
|---|
Search and Browse
