| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50113203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50979 (CHEMBL663522) |
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| Ki | 538±n/a nM |
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| Citation |  Wilson, DM; Termin, AP; Mao, L; Ramirez-Weinhouse, MM; Molteni, V; Grootenhuis, PD; Miller, K; Keim, S; Wise, G Arylamidrazones as novel corticotropin releasing factor receptor antagonists. J Med Chem45:2123-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50113203 |
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| n/a |
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| Name | BDBM50113203 |
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| Synonyms: | (1E)-N-(3-chlorophenyl)-2-oxo-N'-[2-(trifluoromethyl)phenyl]propanehydrazonamide | CHEMBL307751 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClF3N3O |
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| Mol. Mass. | 355.742 |
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| SMILES | CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1C(F)(F)F |w:12.13| |
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| Structure | 
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