Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM50097889 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_71679 (CHEMBL681671) |
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IC50 | 53000±n/a nM |
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Citation | Szabo, CM; Matsumura, Y; Fukura, S; Martin, MB; Sanders, JM; Sengupta, S; Cieslak, JA; Loftus, TC; Lea, CR; Lee, HJ; Koohang, A; Coates, RM; Sagami, H; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem45:2185-96 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM50097889 |
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n/a |
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Name | BDBM50097889 |
Synonyms: | (1-Hydroxy-1-phosphono-hexyl)-phosphonic acid | 1-hydroxyhexane-1,1-diyldiphosphonic acid | CHEMBL299988 |
Type | Small organic molecule |
Emp. Form. | C6H16O7P2 |
Mol. Mass. | 262.1346 |
SMILES | CCCCCC(O)(P(O)(O)=O)P(O)(O)=O |
Structure |
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