| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine--tRNA ligase, mitochondrial |
|---|
| Ligand | BDBM23447 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2045379 (CHEMBL4700078) |
|---|
| EC50 | 7900±n/a nM |
|---|
| Citation |  Zhang, Z; Barros-Álvarez, X; Gillespie, JR; Ranade, RM; Huang, W; Shibata, S; Molasky, NMR; Faghih, O; Mushtaq, A; Choy, RKM; de Hostos, E; Hol, WGJ; Verlinde, CLMJ; Buckner, FS; Fan, E Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against RSC Med Chem11:885-895 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Methionine--tRNA ligase, mitochondrial |
|---|
| Name: | Methionine--tRNA ligase, mitochondrial |
|---|
| Synonyms: | 6.1.1.10 | MARS2 | Methionine--tRNA ligase, mitochondrial | Methionyl-tRNA synthetase 2 | Mitochondrial methionyl-tRNA synthetase | MtMetRS | SYMM_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66605.24 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_120165 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI
GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ
FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA
KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH
VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW
WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT
CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET
YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV
RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG
VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
|
|
|
|---|
| BDBM23447 |
|---|
| n/a |
|---|
| Name | BDBM23447 |
|---|
| Synonyms: | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide | Chloramphenicol | Chlornitromycin | Chloromycetin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H12Cl2N2O5 |
|---|
| Mol. Mass. | 323.129 |
|---|
| SMILES | OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
