Reaction Details |
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Target | Serine/threonine-protein kinase Nek2 |
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Ligand | BDBM50553204 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2045427 (CHEMBL4700126) |
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IC50 | 64±n/a nM |
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Citation | Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Med Chem11:707-731 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Nek2 |
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Name: | Serine/threonine-protein kinase Nek2 |
Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
Type: | Enzyme |
Mol. Mass.: | 51776.96 |
Organism: | Homo sapiens (Human) |
Description: | P51955 |
Residue: | 445 |
Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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BDBM50553204 |
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n/a |
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Name | BDBM50553204 |
Synonyms: | CHEMBL4748191 |
Type | Small organic molecule |
Emp. Form. | C16H14N6O |
Mol. Mass. | 306.322 |
SMILES | CN(C)C(=O)c1ccc(Nc2nc(C#C)c3nc[nH]c3n2)cc1 |
Structure |
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