| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage migration inhibitory factor |
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| Ligand | BDBM50113768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_103857 (CHEMBL712975) |
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| IC50 | 1650±n/a nM |
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| Citation |  Dios, A; Mitchell, RA; Aljabari, B; Lubetsky, J; O'Connor, K; Liao, H; Senter, PD; Manogue, KR; Lolis, E; Metz, C; Bucala, R; Callaway, DJ; Al-Abed, Y Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. J Med Chem45:2410-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage migration inhibitory factor |
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| Name: | Macrophage migration inhibitory factor |
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| Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase |
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| Type: | Enzyme |
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| Mol. Mass.: | 12478.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14174 |
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| Residue: | 115 |
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| Sequence: | MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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| BDBM50113768 |
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| n/a |
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| Name | BDBM50113768 |
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| Synonyms: | (S)-methyl 2-(4-hydroxybenzylideneamino)-3-(1H-indol-3-yl)propanoate | 2-[(4-Hydroxy-benzylidene)-amino]-3-(1H-indol-3-yl)-propionic acid methyl ester | CHEMBL78684 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N2O3 |
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| Mol. Mass. | 322.3578 |
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| SMILES | COC(=O)[C@H](Cc1c[nH]c2ccccc12)\N=C\c1ccc(O)cc1 |r| |
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| Structure | 
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