| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 6 |
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| Ligand | BDBM50553817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2047480 (CHEMBL4702179) |
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| Kd | 290±n/a nM |
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| Citation |  Grädler, U; Busch, M; Leuthner, B; Raba, M; Burgdorf, L; Lehmann, M; Linde, N; Esdar, C Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 6 |
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| Name: | Mitogen-activated protein kinase 6 |
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| Synonyms: | ERK3 | MAPK6 | MK06_HUMAN | PRKM6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82643.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774367 |
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| Residue: | 721 |
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| Sequence: | MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE
QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS
PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC
QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS
TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ
HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG
GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG
FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL
N
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| BDBM50553817 |
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| n/a |
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| Name | BDBM50553817 |
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| Synonyms: | CHEMBL4740226 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N7O |
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| Mol. Mass. | 325.3684 |
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| SMILES | COc1ccc(cc1)-n1nnc2cnc(N[C@@H]3CC[C@@H](N)C3)nc12 |r| |
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| Structure | 
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