| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 6 |
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| Ligand | BDBM120095 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2047482 (CHEMBL4702181) |
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| Kd | 26000±n/a nM |
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| Citation |  Grädler, U; Busch, M; Leuthner, B; Raba, M; Burgdorf, L; Lehmann, M; Linde, N; Esdar, C Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 6 |
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| Name: | Mitogen-activated protein kinase 6 |
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| Synonyms: | ERK3 | MAPK6 | MK06_HUMAN | PRKM6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82643.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774367 |
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| Residue: | 721 |
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| Sequence: | MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE
QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS
PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC
QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS
TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ
HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG
GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG
FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL
N
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| BDBM120095 |
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| n/a |
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| Name | BDBM120095 |
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| Synonyms: | US10525036, Example GDC-0994 | US10934304, Example GDC-0994 | US8697715, 39 | US9259470, 39 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClFN6O2 |
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| Mol. Mass. | 440.858 |
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| SMILES | Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1 |r| |
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| Structure | 
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