| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
|---|
| Ligand | BDBM50114908 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_64361 |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Kitas, EA; Löffler, BM; Daetwyler, S; Dehmlow, H; Aebi, JD Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors. Bioorg Med Chem Lett12:1727-30 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-converting enzyme 1 |
|---|
| Name: | Endothelin-converting enzyme 1 |
|---|
| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 87155.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42892 |
|---|
| Residue: | 770 |
|---|
| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
|
|
|
|---|
| BDBM50114908 |
|---|
| n/a |
|---|
| Name | BDBM50114908 |
|---|
| Synonyms: | (3R,5S)-5-[5-Methylsulfanyl-4-(4-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-yl]-1-(naphthalene-2-sulfonyl)-pyrrolidine-3-thiol | CHEMBL298735 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21F3N4O2S3 |
|---|
| Mol. Mass. | 550.639 |
|---|
| SMILES | CSc1nnc([C@@H]2C[C@@H](S)CN2S(=O)(=O)c2ccc3ccccc3c2)n1-c1ccc(cc1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
