| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor |
|---|
| Ligand | BDBM50077537 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2050317 (CHEMBL4705016) |
|---|
| Ki | 19000±n/a nM |
|---|
| Citation |  Lu, J; Bart, AG; Wu, Q; Criscione, KR; McLeish, MJ; Scott, EE; Grunewald, GL Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine J Med Chem63:13878-13898 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2A adrenergic receptor |
|---|
| Name: | Alpha-2A adrenergic receptor |
|---|
| Synonyms: | ADA2A_RAT | Adra2a | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | CA2-47 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50650.57 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_104693 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLML
FTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVW
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS
FPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKR
RTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRP
RDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGAS
GSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPY
QLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
|
|
|
|---|
| BDBM50077537 |
|---|
| n/a |
|---|
| Name | BDBM50077537 |
|---|
| Synonyms: | (+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol | (7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol | CHEMBL59441 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12N2O3 |
|---|
| Mol. Mass. | 208.2139 |
|---|
| SMILES | OCC1Cc2ccc(cc2CN1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
