| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50549225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2051302 (CHEMBL4706001) |
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| Kd | 750±n/a nM |
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| Citation |  Jahnke, W; Erlanson, DA; de Esch, IJP; Johnson, CN; Mortenson, PN; Ochi, Y; Urushima, T Fragment-to-Lead Medicinal Chemistry Publications in 2019. J Med Chem63:15494-15507 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50549225 |
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| n/a |
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| Name | BDBM50549225 |
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| Synonyms: | CHEMBL4750445 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28N6O2 |
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| Mol. Mass. | 516.593 |
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| SMILES | Cn1cnc(Cn2ccc3ccc(CNCc4[nH]c5ccccc5c4[C@H]4NC(=O)c5ccc(O)cc45)cc23)c1 |r| |
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| Structure | 
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