| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 2 |
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| Ligand | BDBM50116129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_89931 |
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| IC50 | 150±n/a nM |
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| Citation |  Pitts, WJ; Guo, J; Dhar, TG; Shen, Z; Gu, HH; Watterson, SH; Bednarz, MS; Chen, BC; Barrish, JC; Bassolino, D; Cheney, D; Fleener, CA; Rouleau, KA; Hollenbaugh, DL; Iwanowicz, EJ Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase. Bioorg Med Chem Lett12:2137-40 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 2 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 2 |
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| Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55806.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH2 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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| BDBM50116129 |
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| n/a |
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| Name | BDBM50116129 |
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| Synonyms: | CHEMBL307547 | N*3*-(3-Methoxy-4-oxazol-5-yl-phenyl)-1-phenyl-1H-[1,2,4]triazole-3,5-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N6O2 |
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| Mol. Mass. | 348.3586 |
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| SMILES | COc1cc(Nc2nc(N)n(n2)-c2ccccc2)ccc1-c1cnco1 |
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| Structure | 
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