| Reaction Details |
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 | Report a problem with these data |
| Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Ligand | BDBM50556185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2055417 (CHEMBL4710418) |
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| IC50 | 140±n/a nM |
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| Citation |  Liu, L; Kong, C; Fumagalli, M; Savková, K; Xu, Y; Huszár, S; Sammartino, JC; Fan, D; Chiarelli, LR; Miku?ová, K; Sun, Z; Qiao, C Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents. Eur J Med Chem208:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50167.60 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116793 |
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| Residue: | 461 |
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| Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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| BDBM50556185 |
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| n/a |
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| Name | BDBM50556185 |
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| Synonyms: | CHEMBL4752208 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F3N3O3S |
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| Mol. Mass. | 493.542 |
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| SMILES | COC(=O)C#Cc1cc(cc2c1sc(nc2=O)N1CCN(CC2CCCCC2)CC1)C(F)(F)F |
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| Structure | 
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