| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50118044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48931 (CHEMBL665926) |
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| IC50 | 24000±n/a nM |
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| Citation |  Durley, RC; Grapperhaus, ML; Hickory, BS; Massa, MA; Wang, JL; Spangler, DP; Mischke, DA; Parnas, BL; Fobian, YM; Rath, NP; Honda, DD; Zeng, M; Connolly, DT; Heuvelman, DM; Witherbee, BJ; Melton, MA; Glenn, KC; Krul, ES; Smith, ME; Sikorski, JA Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein. J Med Chem45:3891-904 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50118044 |
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| n/a |
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| Name | BDBM50118044 |
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| Synonyms: | 1,1,1-Trifluoro-3-[(3-phenoxy-phenyl)-(3-trifluoromethylsulfanyl-benzyl)-amino]-propan-2-ol | 1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(trifluoromethylthio)benzyl)amino)propan-2-ol | CHEMBL129412 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F6NO2S |
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| Mol. Mass. | 487.458 |
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| SMILES | OC(CN(Cc1cccc(SC(F)(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F |
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| Structure | 
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