Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50118341 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201963 (CHEMBL809149) |
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Ki | 62±n/a nM |
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Citation | Orús, L; Pérez-Silanes, S; Oficialdegui, AM; Martínez-Esparza, J; Del Castillo, JC; Mourelle, M; Langer, T; Guccione, S; Donzella, G; Krovat, EM; Poptodorov, K; Lasheras, B; Ballaz, S; Hervías, I; Tordera, R; Del Río, J; Monge, A Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. J Med Chem45:4128-39 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50118341 |
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n/a |
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Name | BDBM50118341 |
Synonyms: | 1-(5-Fluoro-benzo[b]thiophen-3-yl)-3-(4-naphthalen-1-yl-piperazin-1-yl)-propan-1-ol; | CHEMBL133614 |
Type | Small organic molecule |
Emp. Form. | C25H25FN2OS |
Mol. Mass. | 420.542 |
SMILES | OC(CCN1CCN(CC1)c1cccc2ccccc12)c1csc2ccc(F)cc12 |
Structure |
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