| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50403952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205717 |
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| IC50 | 133±n/a nM |
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| Citation |  Williams, BJ; Cascieri, MA; Chicchi, GG; Harrison, T; Owens, AP; Owen, SN; Rupniak, NM; Tattersall, DF; Williams, A; Swain, CJ Spirocyclic NK(1) antagonists II: [4.5]-spiroethers. Bioorg Med Chem Lett12:2719-22 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50403952 |
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| n/a |
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| Name | BDBM50403952 |
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| Synonyms: | CHEMBL2112367 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23NO |
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| Mol. Mass. | 293.4027 |
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| SMILES | C1OC2(C[C@H]1c1ccccc1)CCCN[C@H]2c1ccccc1 |
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| Structure | 
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