Reaction Details |
| Report a problem with these data |
Target | RAF proto-oncogene serine/threonine-protein kinase |
---|
Ligand | BDBM50557775 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2060072 (CHEMBL4715073) |
---|
Ki | <0.050000±n/a nM |
---|
Citation | Huestis, MP; Durk, MR; Eigenbrot, C; Gibbons, P; Hunsaker, TL; La, H; Leung, DH; Liu, W; Malek, S; Merchant, M; Moffat, JG; Muli, CS; Orr, CJ; Parr, BT; Shanahan, F; Sneeringer, CJ; Wang, W; Yen, I; Yin, J; Rudolph, J; Siu, M Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor. ACS Med Chem Lett12:791-797 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAF proto-oncogene serine/threonine-protein kinase |
---|
Name: | RAF proto-oncogene serine/threonine-protein kinase |
Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 73082.52 |
Organism: | Homo sapiens (Human) |
Description: | P04049 |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
BDBM50557775 |
---|
n/a |
---|
Name | BDBM50557775 |
Synonyms: | CHEMBL4758903 |
Type | Small organic molecule |
Emp. Form. | C27H23FN4O2 |
Mol. Mass. | 454.4955 |
SMILES | Cc1cc(F)c(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1ccc2c(cnn(C)c2=O)c1 |
Structure |
|