Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50119110 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_89935 (CHEMBL699561) |
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IC50 | 380±n/a nM |
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Citation | Iwanowicz, EJ; Watterson, SH; Liu, C; Gu, HH; Mitt, T; Leftheris, K; Barrish, JC; Fleener, CA; Rouleau, K; Sherbina, NZ; Hollenbaugh, DL Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase. Bioorg Med Chem Lett12:2931-4 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50119110 |
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n/a |
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Name | BDBM50119110 |
Synonyms: | CHEMBL99278 | N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N'-cyano-N''-[3-(2-phenoxy-ethoxy)-phenyl]-guanidine |
Type | Small organic molecule |
Emp. Form. | C26H23N5O4 |
Mol. Mass. | 469.4919 |
SMILES | COc1cc(NC(Nc2cccc(OCCOc3ccccc3)c2)=NC#N)ccc1-c1cnco1 |w:24.26| |
Structure |
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