| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM50558241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2062398 (CHEMBL4717651) |
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| Ki | 8.2±n/a nM |
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| Citation |  Yahiaoui, S; Hamidouche, K; Ballandonne, C; Davis, A; de Oliveira Santos, JS; Freret, T; Boulouard, M; Rochais, C; Dallemagne, P Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease. Eur J Med Chem121:283-293 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43735.29 |
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| Organism: | GUINEA PIG |
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| Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
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| Residue: | 388 |
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| Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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| BDBM50558241 |
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| n/a |
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| Name | BDBM50558241 |
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| Synonyms: | CHEMBL4760149 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34ClN3O6S |
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| Mol. Mass. | 540.072 |
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| SMILES | COc1ccc(cc1OC)S(=O)(=O)NCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 |
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| Structure | 
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