| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
|---|
| Ligand | BDBM50559030 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2067515 (CHEMBL4722768) |
|---|
| Kd | 25700±n/a nM |
|---|
| Citation |  Liu, Q; Miao, Y; Wang, X; Lv, G; Peng, Y; Li, K; Li, M; Qiu, L; Lin, J Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. Eur J Med Chem186:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Farnesyl pyrophosphate synthase |
|---|
| Name: | Farnesyl pyrophosphate synthase |
|---|
| Synonyms: | (2E,6E)-farnesyl diphosphate synthase | 2.5.1.1 | 2.5.1.10 | CR 39 | Cholesterol-regulated 39 kDa protein | Dimethylallyltranstransferase | FPP synthase | FPPS_RAT | FPS | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase | Fdps | Geranyltranstransferase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40823.17 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_103143 |
|---|
| Residue: | 353 |
|---|
| Sequence: | MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNR
GLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSYTRRGQICWYQ
KPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLITAPQ
GQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILLEMGEFFQ
IQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRATPQQRQILEENYGQKDPEKVAR
VKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK
|
|
|
|---|
| BDBM50559030 |
|---|
| n/a |
|---|
| Name | BDBM50559030 |
|---|
| Synonyms: | CHEMBL4748453 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H18Cl2N2O6 |
|---|
| Mol. Mass. | 381.209 |
|---|
| SMILES | C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)\C=N\NC(=O)COc1ccc(Cl)cc1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
