| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Ligand | BDBM50559222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2068535 (CHEMBL4723788) |
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| IC50 | >10000±n/a nM |
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| Citation |  Picado, A; Chaikuad, A; Wells, CI; Shrestha, S; Zuercher, WJ; Pickett, JE; Kwarcinski, FE; Sinha, P; de Silva, CS; Zutshi, R; Liu, S; Kannan, N; Knapp, S; Drewry, DH; Willson, TM A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem63:14626-14646 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64746.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_27437015 |
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| Residue: | 588 |
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| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
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| BDBM50559222 |
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| n/a |
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| Name | BDBM50559222 |
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| Synonyms: | CHEMBL4752776 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10N2O2S3 |
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| Mol. Mass. | 358.458 |
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| SMILES | OC(=O)CSc1ncnc2cc(sc12)-c1cc2ccccc2s1 |
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| Structure | 
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