| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 17A |
|---|
| Ligand | BDBM50559222 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2068539 (CHEMBL4723792) |
|---|
| IC50 | 4700±n/a nM |
|---|
| Citation |  Picado, A; Chaikuad, A; Wells, CI; Shrestha, S; Zuercher, WJ; Pickett, JE; Kwarcinski, FE; Sinha, P; de Silva, CS; Zutshi, R; Liu, S; Kannan, N; Knapp, S; Drewry, DH; Willson, TM A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem63:14626-14646 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase 17A |
|---|
| Name: | Serine/threonine-protein kinase 17A |
|---|
| Synonyms: | DRAK1 | ST17A_HUMAN | STK17A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46544.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_109255245 |
|---|
| Residue: | 414 |
|---|
| Sequence: | MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
|
|
|
|---|
| BDBM50559222 |
|---|
| n/a |
|---|
| Name | BDBM50559222 |
|---|
| Synonyms: | CHEMBL4752776 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H10N2O2S3 |
|---|
| Mol. Mass. | 358.458 |
|---|
| SMILES | OC(=O)CSc1ncnc2cc(sc12)-c1cc2ccccc2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
