Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent serotonin transporter |
---|
Ligand | BDBM50121451 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_201797 |
---|
Kd | 0.051±n/a nM |
---|
Citation | Sandell, J; Yu, M; Emond, P; Garreau, L; Chalon, S; Någren, K; Guilloteau, D; Halldin, C Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter. Bioorg Med Chem Lett12:3611-3 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent serotonin transporter |
---|
Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
|
|
|
BDBM50121451 |
---|
n/a |
---|
Name | BDBM50121451 |
Synonyms: | 5-Methyl-6-nitro-2-piperazin-1-yl-quinoline | CHEMBL121952 |
Type | Small organic molecule |
Emp. Form. | C14H16N4O2 |
Mol. Mass. | 272.3024 |
SMILES | Cc1c(ccc2nc(ccc12)N1CCNCC1)[N+]([O-])=O |
Structure |
|