Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-1 | ||
Ligand | BDBM50559303 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2068630 (CHEMBL4723883) | ||
Ki | <1.000000±n/a nM | ||
Citation | Han, W; Ding, Y; Chen, Z; Langowski, JL; Bellamacina, C; Rico, A; Nishiguchi, GA; Lan, J; Atallah, G; Lindvall, M; Lin, S; Zang, R; Feucht, P; Zavorotinskaya, T; Dai, Y; Garcia, P; Burger, MT Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases. J Med Chem63:14885-14904 (2020) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-1 | |||
Name: | Serine/threonine-protein kinase pim-1 | ||
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
Type: | Protein | ||
Mol. Mass.: | 35681.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11309 | ||
Residue: | 313 | ||
Sequence: |
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BDBM50559303 | |||
n/a | |||
Name | BDBM50559303 | ||
Synonyms: | CHEMBL4741855 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H24F3N3O3 | ||
Mol. Mass. | 471.4716 | ||
SMILES | C[C@H]1C[C@H](C[C@@H](O)[C@]1(C)O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:7.9,wD:1.0,5.5,3.10,(30.93,-25.95,;32.26,-26.73,;32.26,-28.27,;33.59,-29.05,;34.92,-28.29,;34.94,-26.75,;36.27,-25.99,;33.6,-25.96,;32.82,-24.63,;34.37,-24.62,;33.57,-30.59,;32.24,-31.35,;32.23,-32.89,;33.56,-33.67,;34.9,-32.91,;34.9,-31.37,;36.25,-30.61,;37.58,-31.38,;37.56,-32.92,;38.91,-30.62,;40.24,-31.4,;41.58,-30.63,;41.59,-29.09,;42.93,-28.33,;40.26,-28.32,;38.92,-29.08,;40.27,-26.78,;38.94,-26,;37.6,-26.76,;38.95,-24.46,;40.29,-23.7,;41.62,-24.47,;41.61,-26.01,;42.93,-26.79,)| | ||
Structure |