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TargetOrexin/Hypocretin receptor type 1
LigandBDBM50121796
Substrate/Competitorn/a
Meas. Tech.ChEMBL_323053 (CHEMBL857324)
EC50 1.5±n/a nM
Citation Asahi, S; Egashira, S; Matsuda, M; Iwaasa, H; Kanatani, A; Ohkubo, M; Ihara, M; Morishima, H Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett13:111-3 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50121796
n/a
NameBDBM50121796
Synonyms:CHEMBL414312 | [Ala16]orexin-B
TypeSmall organic molecule
Emp. Form.C121H209N43O34S
Mol. Mass.2842.287
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O |wU:84.84,79.80,74.75,68.68,120.120,56.56,41.41,100.100,2.2,8.12,182.184,20.20,wD:128.128,152.152,46.45,188.190,111.111,36.36,143.143,4.4,16.16,26.27,92.92,167.169,174.177,(18.35,-19.21,;18.35,-20.75,;17.02,-21.52,;15.68,-20.75,;17.02,-23.06,;18.35,-23.83,;19.68,-23.06,;19.68,-21.52,;21.02,-23.83,;21.02,-25.37,;19.68,-26.14,;19.68,-27.68,;18.35,-25.37,;22.36,-23.06,;23.69,-23.83,;23.69,-25.37,;25.03,-23.06,;26.36,-23.83,;27.69,-23.06,;27.69,-21.52,;29.03,-23.83,;30.36,-23.06,;29.03,-25.37,;27.69,-26.14,;27.7,-27.68,;26.38,-28.46,;25.03,-21.52,;26.36,-20.75,;23.69,-20.75,;15.68,-23.83,;15.68,-25.37,;14.36,-23.07,;13.03,-23.84,;11.69,-23.07,;11.69,-21.53,;10.35,-23.84,;9.02,-23.07,;9.02,-21.53,;7.68,-23.84,;7.68,-25.38,;6.35,-23.07,;5.02,-23.84,;5.02,-25.38,;3.68,-23.07,;3.68,-21.53,;2.35,-23.84,;1.02,-23.07,;1.02,-21.53,;-.32,-20.76,;-1.54,-21.7,;-2.81,-20.83,;-2.37,-19.35,;-.84,-19.31,;-.32,-23.84,;-.32,-25.38,;-1.65,-23.07,;-2.98,-23.84,;-2.98,-25.38,;-4.32,-26.15,;-5.66,-25.38,;-4.32,-27.69,;-4.32,-23.07,;-4.32,-21.53,;-5.66,-23.84,;-6.98,-23.09,;-6.98,-21.54,;-5.65,-20.77,;-8.32,-20.77,;-8.28,-19.26,;-9.57,-18.45,;-9.53,-16.91,;-6.92,-18.51,;-5.61,-19.32,;-6.88,-16.98,;-5.55,-16.21,;-5.55,-14.67,;-4.21,-16.98,;-4.21,-18.52,;-2.88,-16.2,;-2.9,-14.67,;-4.23,-13.91,;-1.55,-13.89,;-1.57,-12.35,;-.22,-14.66,;1.11,-13.89,;1.11,-12.35,;2.45,-11.58,;2.45,-10.04,;3.78,-12.35,;2.45,-14.66,;2.45,-16.2,;3.79,-13.89,;5.12,-14.66,;5.12,-16.2,;6.46,-16.97,;6.46,-18.51,;7.79,-16.2,;6.46,-13.89,;6.46,-12.35,;7.79,-14.66,;9.12,-13.89,;9.12,-12.35,;10.46,-11.58,;10.46,-10.04,;11.8,-9.28,;13.13,-10.05,;14.47,-9.28,;13.14,-11.59,;10.46,-14.66,;10.46,-16.2,;11.79,-13.88,;13.12,-14.65,;13.12,-16.19,;14.46,-16.96,;14.46,-18.5,;15.79,-19.27,;13.12,-19.27,;14.46,-13.88,;14.46,-12.34,;15.79,-14.65,;17.12,-13.88,;17.12,-12.34,;18.46,-11.57,;18.46,-10.03,;19.79,-12.34,;18.46,-14.65,;18.46,-16.19,;19.79,-13.88,;21.12,-14.65,;21.12,-16.19,;22.46,-16.96,;22.46,-18.5,;23.8,-19.27,;25.13,-18.5,;26.47,-19.27,;25.13,-16.96,;22.46,-13.88,;22.46,-12.34,;23.79,-14.65,;25.13,-13.89,;25.13,-12.35,;23.8,-11.58,;26.46,-11.58,;26.47,-10.04,;27.81,-9.28,;27.82,-7.74,;29.16,-6.98,;29.18,-5.44,;30.49,-7.77,;25.14,-9.26,;23.8,-10.02,;25.16,-7.72,;23.83,-6.95,;23.84,-5.43,;25.18,-4.66,;25.18,-3.12,;26.51,-5.43,;22.49,-7.72,;22.49,-9.26,;21.15,-6.95,;19.82,-7.72,;18.49,-6.95,;17.16,-7.72,;18.49,-5.41,;19.74,-4.5,;19.26,-3.04,;17.72,-3.04,;17.24,-4.5,;15.92,-5.28,;15.93,-6.82,;14.57,-4.53,;14.1,-3.07,;12.56,-3.07,;12.08,-4.53,;13.33,-5.44,;13.33,-6.98,;14.66,-7.75,;11.98,-7.76,;10.65,-6.99,;9.31,-7.76,;9.31,-9.3,;7.98,-6.99,;6.65,-7.76,;6.65,-9.3,;5.31,-10.07,;5.31,-6.99,;5.31,-5.45,;3.99,-7.76,;2.66,-6.99,;2.66,-5.45,;1.32,-4.68,;1.32,-3.14,;-0,-2.37,;-1.34,-3.14,;-2.67,-2.37,;-1.34,-4.68,;1.32,-7.76,;-.02,-6.99,;1.32,-9.3,)|
Structure
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