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Compile Data Set for Download or QSAR

Found 233 hits with Last Name = 'asahi' and Initial = 's'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173629
PNG
(CHEMBL197912 | Cyclopentyl-[4-(2-ethyl-4-m-tolyl-t...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC2CCCC2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C22H25N3S/c1-3-20-25-21(16-8-6-7-15(2)13-16)22(26-20)17-11-12-23-19(14-17)24-18-9-4-5-10-18/h6-8,11-14,18H,3-5,9-10H2,1-2H3,(H,23,24)
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n/an/a 3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173614
PNG
(CHEMBL196575 | [4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NCCc2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C25H25N3S/c1-3-23-28-24(20-11-7-8-18(2)16-20)25(29-23)21-13-15-27-22(17-21)26-14-12-19-9-5-4-6-10-19/h4-11,13,15-17H,3,12,14H2,1-2H3,(H,26,27)
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n/an/a 5.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358192
PNG
(CHEMBL1921975)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)[C@@](O)(C(C)C)c1cnc[nH]1 |r|
Show InChI InChI=1S/C19H21N3O2/c1-12(2)19(24,17-10-21-11-22-17)16-7-6-13-8-15(18(23)20-3)5-4-14(13)9-16/h4-12,24H,1-3H3,(H,20,23)(H,21,22)/t19-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173627
PNG
(CHEMBL197581 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)Cc2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C25H23N3OS/c1-3-23-28-24(19-11-7-8-17(2)14-19)25(30-23)20-12-13-26-21(16-20)27-22(29)15-18-9-5-4-6-10-18/h4-14,16H,3,15H2,1-2H3,(H,26,27,29)
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n/an/a 5.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Rattus norvegicus (Rat))		BDBM50338363
PNG
(CHEMBL1682893 | rac-6-[1-Hydroxy-1-(1H-imidazol-4-...)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C(O)(C(C)C)c1cnc[nH]1
Show InChI InChI=1S/C19H21N3O2/c1-12(2)19(24,17-10-21-11-22-17)16-7-6-13-8-15(18(23)20-3)5-4-14(13)9-16/h4-12,24H,1-3H3,(H,20,23)(H,21,22)
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n/an/a 6.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173621
PNG
(Benzyl-[4-(2-ethyl-4-m-tolyl-thiazol-5-yl)-pyridin...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NCc2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C24H23N3S/c1-3-22-27-23(19-11-7-8-17(2)14-19)24(28-22)20-12-13-25-21(15-20)26-16-18-9-5-4-6-10-18/h4-15H,3,16H2,1-2H3,(H,25,26)
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n/an/a 6.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173609
PNG
(CHEMBL363648 | D3RKN_11 | N-[4-(2-Ethyl-4-m-tolyl-...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)
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n/an/a 7.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50109937
PNG
((R)-2-[(Indane-2-carbonyl)-amino]-3-naphthalen-1-y...)
Show SMILES SCCCOC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C26H27NO3S/c28-25(22-15-19-8-1-2-9-20(19)16-22)27-24(26(29)30-13-6-14-31)17-21-11-5-10-18-7-3-4-12-23(18)21/h1-5,7-12,22,24,31H,6,13-17H2,(H,27,28)/t24-/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans

Bioorg Med Chem Lett 12: 629-32 (2002)


BindingDB Entry DOI: 10.7270/Q2251HGT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173606
PNG
(CHEMBL198383 | Cyclohexanecarboxylic acid [4-(2-et...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)C2CCCCC2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C24H27N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h7-8,11-15,17H,3-6,9-10H2,1-2H3,(H,25,26,28)
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n/an/a 7.90n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173617
PNG
(CHEMBL381864 | [4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NCCCc2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C26H27N3S/c1-3-24-29-25(21-13-7-9-19(2)17-21)26(30-24)22-14-16-28-23(18-22)27-15-8-12-20-10-5-4-6-11-20/h4-7,9-11,13-14,16-18H,3,8,12,15H2,1-2H3,(H,27,28)
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n/an/a 8.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173633
PNG
(CHEMBL194201 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)CCc2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C26H25N3OS/c1-3-24-29-25(20-11-7-8-18(2)16-20)26(31-24)21-14-15-27-22(17-21)28-23(30)13-12-19-9-5-4-6-10-19/h4-11,14-17H,3,12-13H2,1-2H3,(H,27,28,30)
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n/an/a 8.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173622
PNG
(CHEMBL199160 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Show SMILES CCC(=O)Nc1cc(ccn1)-c1sc(CC)nc1-c1cccc(C)c1
Show InChI InChI=1S/C20H21N3OS/c1-4-17(24)22-16-12-15(9-10-21-16)20-19(23-18(5-2)25-20)14-8-6-7-13(3)11-14/h6-12H,4-5H2,1-3H3,(H,21,22,24)
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n/an/a 8.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50405453
PNG
(CHEMBL5271309)
Show SMILES CC(C)CCn1c(=O)n(CC(C)C)c2ccc3[nH]cnc3c2c1=O
Show InChI InChI=1S/C18H24N4O2/c1-11(2)7-8-21-17(23)15-14(22(18(21)24)9-12(3)4)6-5-13-16(15)20-10-19-13/h5-6,10-12H,7-9H2,1-4H3,(H,19,20)
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n/an/a 8.90n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173626
PNG
(CHEMBL382103 | {4-[2-(4-Methanesulfonyl-phenyl)-4-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccnc(NCCc2ccccc2)c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C30H27N3O2S2/c1-21-7-6-10-24(19-21)28-29(36-30(33-28)23-11-13-26(14-12-23)37(2,34)35)25-16-18-32-27(20-25)31-17-15-22-8-4-3-5-9-22/h3-14,16,18-20H,15,17H2,1-2H3,(H,31,32)
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n/an/a 9.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50109938
PNG
(9H-Xanthene-9-carboxylic acid {(R)-2-(3,4-dichloro...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)C2c3ccccc3Oc3ccccc23)C(=O)NCCc2cnc[nH]2)cc1Cl
Show InChI InChI=1S/C28H24Cl2N4O3/c29-21-10-9-17(13-22(21)30)14-23(27(35)32-12-11-18-15-31-16-33-18)34-28(36)26-19-5-1-3-7-24(19)37-25-8-4-2-6-20(25)26/h1-10,13,15-16,23,26H,11-12,14H2,(H,31,33)(H,32,35)(H,34,36)/t23-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Candida geranylgeranyl transferase I at 3 uM

Bioorg Med Chem Lett 12: 629-32 (2002)


BindingDB Entry DOI: 10.7270/Q2251HGT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173611
PNG
(Benzyl-{4-[2-(4-methanesulfonyl-phenyl)-4-m-tolyl-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccnc(NCc2ccccc2)c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C29H25N3O2S2/c1-20-7-6-10-23(17-20)27-28(35-29(32-27)22-11-13-25(14-12-22)36(2,33)34)24-15-16-30-26(18-24)31-19-21-8-4-3-5-9-21/h3-18H,19H2,1-2H3,(H,30,31)
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173623
PNG
(CHEMBL383569 | N-[4-(2-Methyl-4-m-tolyl-thiazol-5-...)
Show SMILES Cc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C23H19N3OS/c1-15-7-6-10-18(13-15)21-22(28-16(2)25-21)19-11-12-24-20(14-19)26-23(27)17-8-4-3-5-9-17/h3-14H,1-2H3,(H,24,26,27)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173607
PNG
(CHEMBL197545 | N-[4-(2-Propyl-4-m-tolyl-thiazol-5-...)
Show SMILES CCCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1
Show InChI InChI=1S/C25H23N3OS/c1-3-8-22-28-23(19-12-7-9-17(2)15-19)24(30-22)20-13-14-26-21(16-20)27-25(29)18-10-5-4-6-11-18/h4-7,9-16H,3,8H2,1-2H3,(H,26,27,29)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173638
PNG
(CHEMBL197772 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Show SMILES CCCC(=O)Nc1cc(ccn1)-c1sc(CC)nc1-c1cccc(C)c1
Show InChI InChI=1S/C21H23N3OS/c1-4-7-18(25)23-17-13-16(10-11-22-17)21-20(24-19(5-2)26-21)15-9-6-8-14(3)12-15/h6,8-13H,4-5,7H2,1-3H3,(H,22,23,25)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358195
PNG
(CHEMBL1921979)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C1CCn2cncc12
Show InChI InChI=1S/C18H17N3O/c1-19-18(22)15-5-3-12-8-14(4-2-13(12)9-15)16-6-7-21-11-20-10-17(16)21/h2-5,8-11,16H,6-7H2,1H3,(H,19,22)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173630
PNG
(4-[2-(4-Methanesulfonyl-phenyl)-4-m-tolyl-thiazol-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccncc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H18N2O2S2/c1-15-4-3-5-18(14-15)20-21(16-10-12-23-13-11-16)27-22(24-20)17-6-8-19(9-7-17)28(2,25)26/h3-14H,1-2H3
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Rattus norvegicus (Rat))		BDBM50358195
PNG
(CHEMBL1921979)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C1CCn2cncc12
Show InChI InChI=1S/C18H17N3O/c1-19-18(22)15-5-3-12-8-14(4-2-13(12)9-15)16-6-7-21-11-20-10-17(16)21/h2-5,8-11,16H,6-7H2,1H3,(H,19,22)
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173628
PNG
(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridine | CHEM...)
Show SMILES CCc1nc(c(s1)-c1ccncc1)-c1cccc(C)c1
Show InChI InChI=1S/C17H16N2S/c1-3-15-19-16(14-6-4-5-12(2)11-14)17(20-15)13-7-9-18-10-8-13/h4-11H,3H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50338363
PNG
(CHEMBL1682893 | rac-6-[1-Hydroxy-1-(1H-imidazol-4-...)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C(O)(C(C)C)c1cnc[nH]1
Show InChI InChI=1S/C19H21N3O2/c1-12(2)19(24,17-10-21-11-22-17)16-7-6-13-8-15(18(23)20-3)5-4-14(13)9-16/h4-12,24H,1-3H3,(H,20,23)(H,21,22)
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n/an/a 16n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50109933
PNG
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Show SMILES OC(CS)C(CS)OC(=O)c1csc(n1)C1COc2ccccc2O1
Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2
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n/an/a 17n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans

Bioorg Med Chem Lett 12: 629-32 (2002)


BindingDB Entry DOI: 10.7270/Q2251HGT
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50109933
PNG
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Show SMILES OC(CS)C(CS)OC(=O)c1csc(n1)C1COc2ccccc2O1
Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2
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n/an/a 17n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans

Bioorg Med Chem Lett 12: 629-32 (2002)


BindingDB Entry DOI: 10.7270/Q2251HGT
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50405449
PNG
(CHEMBL5266711)
Show SMILES COCc1nc2c(ccc3n(CC(C)C)c(=O)n(C)c(=O)c23)[nH]1
Show InChI InChI=1S/C16H20N4O3/c1-9(2)7-20-11-6-5-10-14(18-12(17-10)8-23-4)13(11)15(21)19(3)16(20)22/h5-6,9H,7-8H2,1-4H3,(H,17,18)
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50239947
PNG
(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Show SMILES COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
Show InChI InChI=1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50239943
PNG
(CHEMBL4099869 | US9872852, Example 8)
Show SMILES Cc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1
Show InChI InChI=1S/C27H28BrNO3/c1-19-22(10-7-11-23(19)21-8-3-2-4-9-21)18-32-26-14-13-20(16-24(26)28)17-29-15-6-5-12-25(29)27(30)31/h2-4,7-11,13-14,16,25H,5-6,12,15,17-18H2,1H3,(H,30,31)
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50239947
PNG
(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Show SMILES COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
Show InChI InChI=1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50405450
PNG
(CHEMBL5315609)
Show SMILES CC(C)Cn1c2ccc3[nH]c(C)nc3c2c(=O)n(C)c1=O
Show InChI InChI=1S/C15H18N4O2/c1-8(2)7-19-11-6-5-10-13(17-9(3)16-10)12(11)14(20)18(4)15(19)21/h5-6,8H,7H2,1-4H3,(H,16,17)
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358201
PNG
(CHEMBL1921976 | US9611270, orteronel)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)[C@@]1(O)CCn2cncc12 |r|
Show InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173612
PNG
(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-ylami...)
Show SMILES CCc1nc(c(s1)-c1ccnc(N)c1)-c1cccc(C)c1
Show InChI InChI=1S/C17H17N3S/c1-3-15-20-16(12-6-4-5-11(2)9-12)17(21-15)13-7-8-19-14(18)10-13/h4-10H,3H2,1-2H3,(H2,18,19)
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50405449
PNG
(CHEMBL5266711)
Show SMILES COCc1nc2c(ccc3n(CC(C)C)c(=O)n(C)c(=O)c23)[nH]1
Show InChI InChI=1S/C16H20N4O3/c1-9(2)7-20-11-6-5-10-14(18-12(17-10)8-23-4)13(11)15(21)19(3)16(20)22/h5-6,9H,7-8H2,1-4H3,(H,17,18)
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n/an/a 22n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Rattus norvegicus (Rat))		BDBM50358197
PNG
(CHEMBL1921981)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C1(O)CCn2cncc12
Show InChI InChI=1S/C17H15N3O2/c18-16(21)13-2-1-12-8-14(4-3-11(12)7-13)17(22)5-6-20-10-19-9-15(17)20/h1-4,7-10,22H,5-6H2,(H2,18,21)
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173608
PNG
(CHEMBL371920 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(C)=O)c1)-c1cccc(C)c1
Show InChI InChI=1S/C19H19N3OS/c1-4-17-22-18(14-7-5-6-12(2)10-14)19(24-17)15-8-9-20-16(11-15)21-13(3)23/h5-11H,4H2,1-3H3,(H,20,21,23)
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173616
PNG
(4-[2-(4-Methanesulfonyl-phenyl)-4-m-tolyl-thiazol-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccnc(C)c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H20N2O2S2/c1-15-5-4-6-18(13-15)21-22(19-11-12-24-16(2)14-19)28-23(25-21)17-7-9-20(10-8-17)29(3,26)27/h4-14H,1-3H3
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358197
PNG
(CHEMBL1921981)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C1(O)CCn2cncc12
Show InChI InChI=1S/C17H15N3O2/c18-16(21)13-2-1-12-8-14(4-3-11(12)7-13)17(22)5-6-20-10-19-9-15(17)20/h1-4,7-10,22H,5-6H2,(H2,18,21)
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n/an/a 29n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173637
PNG
(CHEMBL194595 | N-{4-[4-(3-Chloro-phenyl)-2-ethyl-t...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H18ClN3OS/c1-2-20-27-21(16-9-6-10-18(24)13-16)22(29-20)17-11-12-25-19(14-17)26-23(28)15-7-4-3-5-8-15/h3-14H,2H2,1H3,(H,25,26,28)
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n/an/a 30n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173618
PNG
(CHEMBL371188 | N-[4-(2-Ethyl-4-phenyl-thiazol-5-yl...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C23H19N3OS/c1-2-20-26-21(16-9-5-3-6-10-16)22(28-20)18-13-14-24-19(15-18)25-23(27)17-11-7-4-8-12-17/h3-15H,2H2,1H3,(H,24,25,27)
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n/an/a 31n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173619
PNG
(CHEMBL425909 | N-{4-[2-Ethyl-4-(4-fluoro-phenyl)-t...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H18FN3OS/c1-2-20-27-21(15-8-10-18(24)11-9-15)22(29-20)17-12-13-25-19(14-17)26-23(28)16-6-4-3-5-7-16/h3-14H,2H2,1H3,(H,25,26,28)
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n/an/a 31n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50109940
PNG
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)
Show SMILES OC(CS)COC(=O)c1csc(n1)C1COc2ccccc2O1
Show InChI InChI=1S/C15H15NO5S2/c17-9(7-22)5-20-15(18)10-8-23-14(16-10)13-6-19-11-3-1-2-4-12(11)21-13/h1-4,8-9,13,17,22H,5-7H2
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n/an/a 31n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans

Bioorg Med Chem Lett 12: 629-32 (2002)


BindingDB Entry DOI: 10.7270/Q2251HGT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173632
PNG
(CHEMBL197799 | N-{4-[2-(4-Methanesulfonyl-phenyl)-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccnc(NC(=O)Cc2ccccc2)c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C30H25N3O3S2/c1-20-7-6-10-23(17-20)28-29(37-30(33-28)22-11-13-25(14-12-22)38(2,35)36)24-15-16-31-26(19-24)32-27(34)18-21-8-4-3-5-9-21/h3-17,19H,18H2,1-2H3,(H,31,32,34)
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173613
PNG
(CHEMBL371716 | N-{4-[2-(4-Methanesulfonyl-phenyl)-...)
Show SMILES Cc1cccc(c1)-c1nc(sc1-c1ccnc(NC(=O)c2ccccc2)c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C29H23N3O3S2/c1-19-7-6-10-22(17-19)26-27(36-29(32-26)21-11-13-24(14-12-21)37(2,34)35)23-15-16-30-25(18-23)31-28(33)20-8-4-3-5-9-20/h3-18H,1-2H3,(H,30,31,33)
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n/an/a 37n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358193
PNG
(CHEMBL1921977)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C1(O)CCn2cncc12
Show InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)
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n/an/a 38n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50405450
PNG
(CHEMBL5315609)
Show SMILES CC(C)Cn1c2ccc3[nH]c(C)nc3c2c(=O)n(C)c1=O
Show InChI InChI=1S/C15H18N4O2/c1-8(2)7-19-11-6-5-10-13(17-9(3)16-10)12(11)14(20)18(4)15(19)21/h5-6,8H,7H2,1-4H3,(H,16,17)
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n/an/a 43n/an/an/an/an/an/a


TBA

Assay Description
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin

Citation and Details
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Homo sapiens (Human))		BDBM50358202
PNG
(CHEMBL1921985)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)[C@]1(O)CCn2cncc12 |r|
Show InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of human CYP17A1

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Steroid 17-alpha-hydroxylase/17,20 lyase


(Rattus norvegicus (Rat))		BDBM50358201
PNG
(CHEMBL1921976 | US9611270, orteronel)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)[C@@]1(O)CCn2cncc12 |r|
Show InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50173636
PNG
(4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-2-methyl-pyridi...)
Show SMILES CCc1nc(c(s1)-c1ccnc(C)c1)-c1cccc(C)c1
Show InChI InChI=1S/C18H18N2S/c1-4-16-20-17(14-7-5-6-12(2)10-14)18(21-16)15-8-9-19-13(3)11-15/h5-11H,4H2,1-3H3
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n/an/a 53n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha

J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase


(Rattus norvegicus (Rat))		BDBM50358193
PNG
(CHEMBL1921977)
Show SMILES CNC(=O)c1ccc2cc(ccc2c1)C1(O)CCn2cncc12
Show InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)
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n/an/a 54n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 m...

Bioorg Med Chem 19: 6383-99 (2011)


Article DOI: 10.1016/j.bmc.2011.08.066
BindingDB Entry DOI: 10.7270/Q2X63NDF
More data for this
Ligand-Target Pair
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