Reaction Details |
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Target | Sphingomyelin phosphodiesterase 2 |
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Ligand | BDBM50122309 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144777 (CHEMBL751443) |
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Ki | 1600±n/a nM |
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Citation | Yokomatsu, T; Murano, T; Akiyama, T; Koizumi, J; Shibuya, S; Tsuji, Y; Soeda, S; Shimeno, H Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity. Bioorg Med Chem Lett13:229-36 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sphingomyelin phosphodiesterase 2 |
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Name: | Sphingomyelin phosphodiesterase 2 |
Synonyms: | Lyso-PAF-PLC | Lyso-platelet-activating factor-phospholipase C | N-SMase | NSMA_HUMAN | Neutral sphingomyelinase | SMPD2 | Sphingomyelin phosphodiesterase 2 | nSMase |
Type: | PROTEIN |
Mol. Mass.: | 47650.63 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_144777 |
Residue: | 423 |
Sequence: | MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLR
QKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGL
LVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLN
MHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYV
LYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERS
PLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTP
SVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRT
KEQ
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BDBM50122309 |
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n/a |
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Name | BDBM50122309 |
Synonyms: | ((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydroxy-4-phenyl-butyl)-phosphonic acid | CHEMBL310981 |
Type | Small organic molecule |
Emp. Form. | C26H44F2NO5P |
Mol. Mass. | 519.6018 |
SMILES | CCCCCCCCCCCCCCCC(=O)N[C@@H](CC(F)(F)P(O)(O)=O)[C@H](O)c1ccccc1 |
Structure |
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