| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase FRK |
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| Ligand | BDBM255338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2071889 (CHEMBL4727423) |
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| IC50 | 154±n/a nM |
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| Citation |  Liu, J; Guiadeen, D; Krikorian, A; Gao, X; Wang, J; Babu Boga, S; Alhassan, AB; Yu, W; Selyutin, O; Yu, Y; Anand, R; Xu, J; Kelly, J; Duffy, JL; Liu, S; Yang, C; Wu, H; Cai, J; Bennett, C; Maloney, KM; Tyagarajan, S; Gao, YD; Fischmann, TO; Presland, J; Mansueto, M; Xu, Z; Leccese, E; Zhang-Hoover, J; Knemeyer, I; Garlisi, CG; Stivers, P; Brandish, PE; Hicks, A; Kim, R; Kozlowski, JA Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase FRK |
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| Name: | Tyrosine-protein kinase FRK |
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| Synonyms: | FRK | FRK_HUMAN | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | RAK | SRC | Tyrosine Kinase FRK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 58254.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42685 |
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| Residue: | 505 |
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| Sequence: | MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
ETLRWKLEDYFETDSSYSDANNFIR
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| BDBM255338 |
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| n/a |
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| Name | BDBM255338 |
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| Synonyms: | US9481682, 116 | US9481682, 88 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26F3N7O3 |
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| Mol. Mass. | 565.5463 |
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| SMILES | COc1cc(ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F |r| |
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| Structure | 
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