| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50560758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2073000 (CHEMBL4728534) |
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| IC50 | 213±n/a nM |
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| Citation |  Codony, S; Pujol, E; Pizarro, J; Feixas, F; Valverde, E; Loza, MI; Brea, JM; Saez, E; Oyarzabal, J; Pineda-Lucena, A; Pérez, B; Pérez, C; Rodríguez-Franco, MI; Leiva, R; Osuna, S; Morisseau, C; Hammock, BD; Vázquez-Carrera, M; Vázquez, S 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: J Med Chem63:9237-9257 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50560758 |
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| n/a |
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| Name | BDBM50560758 |
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| Synonyms: | CHEMBL4800149 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H29N3O3 |
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| Mol. Mass. | 347.4519 |
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| SMILES | O=C(NC1CCN(CC1)C(=O)C1CC1)NC12CC3CC(CC(C3)O1)C2 |TLB:14:15:18.17.22:20,THB:16:17:20:24.15.23,16:15:18.17.22:20,23:15:18:22.21.20,23:21:18:24.16.15,14:15:18:22.21.20| |
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| Structure | 
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