Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50123354 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_89930 |
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IC50 | 25±n/a nM |
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Citation | Dhar, TG; Watterson, SH; Chen, P; Shen, Z; Gu, HH; Norris, D; Carlsen, M; Haslow, KD; Pitts, WJ; Guo, J; Chorba, J; Fleener, CA; Rouleau, KA; Townsend, R; Hollenbaugh, D; Iwanowicz, EJ Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett13:547-51 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50123354 |
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n/a |
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Name | BDBM50123354 |
Synonyms: | 7-Methoxy-6-oxazol-5-yl-2-(3-pyrrolidin-1-yl-phenyl)-1H-quinolin-4-one | CHEMBL153702 |
Type | Small organic molecule |
Emp. Form. | C23H21N3O3 |
Mol. Mass. | 387.4311 |
SMILES | COc1cc2nc(cc(O)c2cc1-c1cnco1)-c1cccc(c1)N1CCCC1 |
Structure |
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