Reaction Details |
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Target | Dihydropyrimidine dehydrogenase [NADP(+)] |
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Ligand | BDBM50124201 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_53186 |
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IC50 | 97±n/a nM |
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Citation | Hattori, K; Kohchi, Y; Oikawa, N; Suda, H; Ura, M; Ishikawa, T; Miwa, M; Endoh, M; Eda, H; Tanimura, H; Kawashima, A; Horii, I; Ishitsuka, H; Shimma, N Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett13:867-72 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydropyrimidine dehydrogenase [NADP(+)] |
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Name: | Dihydropyrimidine dehydrogenase [NADP(+)] |
Synonyms: | DHPDHase | DPD | DPYD | DPYD_HUMAN | Dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase [NADP+] | Dihydrothymine dehydrogenase | Dihydrouracil dehydrogenase |
Type: | PROTEIN |
Mol. Mass.: | 111404.27 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_53186 |
Residue: | 1025 |
Sequence: | MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC
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BDBM50124201 |
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n/a |
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Name | BDBM50124201 |
Synonyms: | 5-(3-Benzyloxy-benzyl)-1H-pyrimidine-2,4-dione | CHEMBL127691 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O3 |
Mol. Mass. | 308.3312 |
SMILES | O=c1[nH]cc(Cc2cccc(OCc3ccccc3)c2)c(=O)[nH]1 |
Structure |
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